Cancer-specific Studies in the NCI Division of Cancer Epidemiology and Genetics
Body Size, Physical Activity, and Renal Cell Cancer
The NIH-AARP Diet and Health Study analyzed the association between body mass index (BMI) and physical activity to renal cell cancer (RCC). Weight gain in early (18-35 years of age) and mid- (35-50 years of age) adulthood was strongly associated with RCC, whereas weight gain after midlife (age 50 years to baseline) was unrelated. Waist-to-hip ratio was positively associated with RCC in women and with height at age 18 years in both men and women. Increased physical activity, including activity during adolescence, was associated with reduced risk of RCC.
Physical Activity and Renal Cell Cancer in Cohort of Male Smokers
A cohort of approximately 30,000 male smokers 50-69 years of age in the Alpha-Tocopherol, Beta-Carotene (ATBC) Cancer Prevention Study examined the association between leisure-time and occupational physical activity and renal cell cancer (RCC). Data suggest that recreational physical activity may play a role in the prevention of RCC in men.
Central and Easter Europe Kidney Cancer
This hospital-based case-control study of kidney cancer evaluated occupational and other risk factors for kidney cancer in seven centers across the central and eastern Europe. The study found an increased risk for self-reported hypertension and for obesity, which are likely to contribute in part to the high rate in this region.