Cancer-specific Studies in the NCI Division of Cancer Epidemiology and Genetics
Physical Activity and Prostate Cancer
The NIH-AARP Diet and Health Study investigated physical activity in relation to prostate cancer among white men and African-American men, who have much higher incidence rates. Results are summarized on the web site.
Prostate Cancer Study in Shanghai
This population-based multidisciplinary case-control study was conducted in Shanghai, China to investigate the reasons for the extremely low risk of prostate cancer in China and to evaluate factors that might explain the recent increase in incidence in this low-risk population. Results to date suggest that higher levels of education, a high waist-to-hip ratio (an indicator of central obesity), and a higher intake of total calories, red meat, and animal fat and protein are associated with an increased risk.
Prostate Cancer in the PLCO Cancer Screening Trial Cohort
A nested case-control study within the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial is evaluating the role of obesity, insulin resistance, and chronic inflammation. The ongoing study includes both a serum-based component to evaluate metabolic markers associated with insulin resistance and a genetic component to assess susceptibility in genes involved in the insulin signaling and chronic inflammation pathways.