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In this section:
Mission
Vision
Goals
Definition of Public Health Genomics (PHG)
The Need for PHG Research
Current NCI Genomics Translational Research
Public Health Genomics Interest Group (PHGIG)
Papers of Interest
Contacts
Mission: To integrate genomics into public health cancer research, policy, and programs.
Vision: To use genomic knowledge to reduce the burden of cancer.
Goals: To improve public health interventions of cancer through these major projects or initiatives:
Knowledge Synthesis
Genomics Translation Research
Comparative Effectiveness Research
GAPPNet 
EGAPP
HuGE
Training and education
Definition of Public Health Genomics (PHG)
"A multidisciplinary field concerned with the effective and responsible translation of genome based knowledge and technologies to improve population health" (Bellagio Statement, 2006).
For more information please see:
The Bellagio Statement
What is PHG and why should we care?
A presentation from Muin Khoury
The evidence dilemma in genomic medicine
The Need for PHG Research
With the accelerating pace of discoveries of human genetic variation, epigenetic, molecular, biochemical and cellular technologies for cancer care and prevention, there is an urgent need to develop clinical and population-level research, policy and practice processes to translate basic science discoveries into actions that reduce the population burden of cancer in the United States.
The emerging scientific translation needs in the genomics era are substantial. Population sciences are now urgently needed to assess the distribution of genetic variants and their products biomarkers, and interactions with other genes and environmental factors. New methods are needed to assess the contribution of genes and gene-environment interactions (behavior, nutrition, chemicals, and other exposures) to individual and population risks for various cancers. Behavioral and social sciences are needed to assess how genetic information can be used to effect behavior change to reduce the burden of cancer. As importantly, delivery research on clinical utility, effectiveness, and economics of genomics-based health care applications are needed to assess their added value in cancer care and prevention. Genomics and related fields will also affect surveillance, dissemination and diffusion research as well as evaluation of cancer progression and survivorship. Without the expansion of population sciences in genomics, the promise of genome research and discoveries may not reach its full potential.
Current NCI Genomics Translational Research
An exhaustive search of the FY2007 NCI grant portfolio resulted in 19 funded genomics applications that were considered "translational". View a list of funded grants: http://cancercontrol.cancer.gov/od/phg/research.asp?type=genomics.
Public Health Genomics Interest Group (PHGIG)
A trans-NIH Public Health Genomics Interest Group has been created. This group will lead NIH regarding scientific input on PHG training, workshops, and initiatives.
Sign up for the PHGIG listserv – (NIH only)
Papers of Interest
The continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention
Will genomics widen or help heal the schism between medicine and public health?
Contacts
Sheri Dixon Schully, PhD
Public Health Genomics Coordinator, Division of Cancer Control and Population Sciences, NCI
schullys@mail.nih.gov
Muin J. Khoury MD, PhD
Director, National Office of Public Health Genomics, CDC
Public Health Genomics Liaison, Division of Cancer Control and Population Sciences, NCI
mkhoury@cdc.gov |
